Transforming Suzuki鈥揗iyaura Cross-Couplings of MIDA Boronates into a Green Technology: No Organic Solvents

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• 作者：Nicholas A. Isley ; Fabrice Gallou ; Bruce H. Lipshutz
• 刊名：Journal of the American Chemical Society
• 出版年：2013
• 出版时间：November 27, 2013
• 年：2013
• 卷：135
• 期：47
• 页码：17707-17710
• 全文大小：307K
• 年卷期：v.135,no.47(November 27, 2013)
• ISSN：1520-5126

文摘

New technology has been developed that enables Suzuki鈥揗iyaura couplings involving widely utilized MIDA boronates to be run in water as the only medium, mainly at room temperature. The protocol is such that no organic solvent is involved at any stage; from the reaction through to product isolation. Hence, using the E factor scale as a measure of greenness, the values for these cross-couplings approach zero.