Insecticides in Chinese Medicinal Plants: Survey Leading to Jacaranone, A Neurotoxicant and Glutathione-Reactive Quinol
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- 作者：Hanhong Xu ; Nanjing Zhang ; and John E. Casida
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2003
- 出版时间：April 23, 2003
- 年：2003
- 卷：51
- 期：9
- 页码：2544 - 2547
- 全文大小：72K
- 年卷期：v.51,no.9(April 23, 2003)
- ISSN：1520-5118
文摘
Sixty-two plant species from central China were purported to have insecticidal activity. Adult housefly (Musca domestica) toxicity assays were used to identify the two most active plants and guide thechromatographic isolation of the insecticidal components. The active ingredient of Senecio palmatusPall. (Asteraceae) was characterized as methyl (1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)acetate(jacaranone) (1), previously known to have insect antifeedant activity. Mono- and bisglutathione (GSH)adducts are formed on incubation of 1 with GSH and rat liver GSH S-transferase. The toxic action of1 in mice (intraperitoneal LD50 = 150-200 mg/kg) is associated with both neurological signs andGSH depletion in liver 90 min after treatment. Paeonia suffruticosa var. papaveracea (Andr.) Kerner(Paeoniaceae) was the other active plant found here to have 2'-hydroxy-4'-methoxyacetophenone(paeonol) (2) as an insecticidal ingredient in the root and in one case, for the whole plant, contaminatedwith S-tert-butylthiomethyl O,O-diethyl phosphorodithioate (terbufos) (3), a synthetic anticholinesteraseinsecticide.Keywords: Glutathione conjugates; insecticide; jacaranone; paeonol; terbufos