Rh-Catalyzed N–O Bond Cleavage of Anthranil: A C–H Amination Reagent for Simultaneous Incorporation of Amine and a Functional Group

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• 作者：Miancheng Zou ; Jianzhong Liu ; Conghui Tang ; Ning Jiao
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：June 17, 2016
• 年：2016
• 卷：18
• 期：12
• 页码：3030-3033
• 全文大小：455K
• 年卷期：0
• ISSN：1523-7052

文摘

A novel Rh(III)-catalyzed C–H bond amination with the simultaneous release of a formyl group at distal positions is realized employing anthranil as a new type of C–H amination reagent. This chemistry provides an efficient protocol for the synthesis of 2-acyl diarylamines, which are important structural motifs in many bioactive compounds. This new type of C–H amination reagent possesses the advantages of high atom economy, avoids the use of external oxidants, and enables further transformation of the amination products.