Asymmetric Synthesis of -Hydroxy Sulfides Controlled by Remote Sulfoxides

详细信息    查看全文

• 作者：Yolanda Arroyo ; J. Fé ; lix Rodrí ; guez ; Mercedes Santos ; M. Ascensi&oacute ; n Sanz Tejedor ; José ; Luis Garcí ; a Ruano
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：February 2, 2007
• 年：2007
• 卷：72
• 期：3
• 页码：1035 - 1038
• 全文大小：77K
• 年卷期：v.72,no.3(February 2, 2007)
• ISSN：1520-6904

文摘

LE>GR ID=jo062053qn00001>ls/joceah/72/i03/figures/jo062053qn00001.gif" ALIGN="left" HSPACE=5>Reactions of (S)-ges/gifchars/alpha.gif" BORDER=0>-(methylthio)-2-(p-tolylsulfinyl)benzyl carbanion with different carbonyl compounds proceeds withcomplete control of the configuration at the benzylic position.Aldehydes yield easily separable mixtures of ges/gifchars/beta2.gif" BORDER=0 ALIGN="middle">-hydroxysulfides, epimers at the hydroxylic carbon, where thestereoselectivity depends on steric factors (from 20% to>98% de).