An Approach to Prepare Polyethylenimine Functionalized Silica-Based Spheres with Small Size for siRNA Delivery
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- 作者：Meihua Yu ; Yuting Niu ; Yannan Yang ; Sandy Budi Hartono ; Jie Yang ; Xiaodan Huang ; Peter Thorn ; Chengzhong Yu
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2014
- 出版时间：September 24, 2014
- 年：2014
- 卷：6
- 期：18
- 页码：15626-15631
- 全文大小：414K
- ISSN：1944-8252
文摘
A novel approach has been developed to prepare polyethylenimine functionalized hybrid silica spheres with a diameter of 鈭?0 nm, which show excellent delivery efficiency of siRNA into osteosarcoma cancer cells and human colon cancer cells with a significant cell inhibition comparable to commercial agents.