NIR-to-NIR Two-Photon Excited CaF2:Tm3+,Yb3+ Nanoparticles: Multifunctional Nanoprobes for Highly Penetrating Fluorescence Bio-Imaging

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• 作者：Ning-Ning Dong ; Marco Pedroni ; Fabio Piccinelli ; Giamaica Conti ; Andrea Sbarbati ; Juan Enrique Ramírez-Hernández ; Laura Martínez Maestro ; Maria Carmen Iglesias-de la Cruz ; Francisco Sanz-Rodriguez ; Angeles Juarranz ; Feng Chen ; Fiorenzo Vetrone ; John A. Capobianco ; José García Solé ; Marco Bettinelli ; Daniel Jaque ; Adolfo Speghini
• 刊名：ACS Nano
• 出版年：2011
• 出版时间：November 22, 2011
• 年：2011
• 卷：5
• 期：11
• 页码：8665-8671
• 全文大小：903K
• 年卷期：0
• ISSN：1936-086X

文摘

In this study, we report on the remarkable two-photon excited fluorescence efficiency in the “biological window” of CaF₂:Tm³⁺,Yb³⁺ nanoparticles. On the basis of the strong Tm³⁺ ion emission (at around 800 nm), tissue penetration depths as large as 2 mm have been demonstrated, which are more than 4 times those achievable based on the visible emissions in comparable CaF₂:Er³⁺,Yb³⁺ nanoparticles. The outstanding penetration depth, together with the fluorescence thermal sensitivity demonstrated here, makes CaF₂:Tm³⁺,Yb³⁺ nanoparticles ideal candidates as multifunctional nanoprobes for high contrast and highly penetrating in vivo fluorescence imaging applications.