Thiodiketopiperazines from the Marine-Derived Fungus Phoma sp. OUCMDZ-1847

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• 作者：Fandong Kong ; Yi Wang ; Peipei Liu ; Tianhan Dong ; Weiming Zhu
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：January 24, 2014
• 年：2014
• 卷：77
• 期：1
• 页码：132-137
• 全文大小：338K
• ISSN：1520-6025

文摘

Three new thiodiketopiperazines, named phomazines A鈥揅 (1鈥?b>3), along with 10 known analogues (4鈥?b>13), were isolated from the fermentation broth of an endophytic fungus, Phoma sp. OUCMDZ-1847, associated with the mangrove plant Kandelia candel. The structures including the absolute configurations of the new compounds were unambiguously elucidated by spectroscopic, X-ray crystallographic, and Mosher鈥檚 methods along with quantum ECD and ¹³C NMR calculations. Compounds 2, 4, 5, 11, and 12 showed cytotoxicities against the HL-60, HCT-116, K562, MGC-803, and A549 cell lines with IC₅₀ values in the range 0.05 to 8.5 渭M.