Poly(ε-caprolactone)/Poly(ethylene glycol)/Poly(ε-caprolactone) Nanoparticles: Preparation, Characterization, and Application in Doxorubicin Delivery
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- 作者：MaLing Gou ; XiuLing Zheng ; Ke Men ; Juan Zhang ; Lan Zheng ; XiuHong Wang ; Feng Luo ; YinLan Zhao ; Xia Zhao ; YuQuan Wei ; ZhiYong Qian
- 刊名：Journal of Physical Chemistry B
- 出版年：2009
- 出版时间：October 1, 2009
- 年：2009
- 卷：113
- 期：39
- 页码：12928-12933
- 全文大小：415K
- 年卷期：v.113,no.39(October 1, 2009)
- ISSN：1520-5207
文摘
Biodegradable poly(ε-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymer nanoparticles showed potential application in drug delivery systems. In this article, monodisperse poly(ε-caprolactone)/poly(ethylene glycol)/poly(ε-caprolactone) (PCL/PEG/PCL, PCEC) nanoparticles, 40 nm, were prepared by solvent extraction method using acetone as the organic solvent. These PCL/PEG/PCL nanoparticles did not induce hemolysis in vitro and did not show toxicity in vitro or in vivo. The prepared PCL/PEG/PCL nanoparticles were employed to load doxorubicin by a pH-induced self-assembly method. In vitro release study indicated that doxorubicin release from nanoparticles at pH 5.5 was faster than that at pH 7.0. The encapsulation of doxorubicin in PCL/PEG/PCL nanoparticles enhanced the cytotoxicity of doxorubicin on a C-26 cell line in vitro. Meanwhile, compared with free doxorubicin, doxorubicin in nanoparticles could more efficiently treat mice bearing subcutaneous C-26 tumors. The doxorubicin-loaded PCL/PEG/PCL nanoparticles might be a novel doxorubicin formulation for cancer therapy.