Efficient Synthesis and Stereochemical Revision of Coibamide A

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• 作者：Guiyang Yao ; Zhengyin Pan ; Chunlei Wu ; Wei Wang ; Lijing Fang ; Wu Su
• 刊名：Journal of the American Chemical Society
• 出版年：2015
• 出版时间：October 28, 2015
• 年：2015
• 卷：137
• 期：42
• 页码：13488-13491
• 全文大小：291K
• ISSN：1520-5126

文摘

Coibamide A is a highly potent antiproliferative cyclodepsipeptide originally isolated from a Panamanian marine cyanobacterium. Herein we report an efficient solid-phase strategy for assembly of highly N-methylated cyclodepsipeptides, which is invaluable in generating coibamide A derivatives for structure鈥揳ctivity relationship studies. As a consequence of our synthetic studies, two stereochemical assignments of coibamide A were revised and the total synthesis of this natural compound was achieved for the first time.