Catalytic Nazarov Reaction of Aryl Vinyl Ketones via Binary Acid Strategy
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- 作者：Zhi-Guo Xi ; Lihui Zhu ; Sanzhong Luo ; Jin-Pei Cheng
- 刊名：The Journal of Organic Chemistry
- 出版年：2013
- 出版时间：January 18, 2013
- 年：2013
- 卷：78
- 期：2
- 页码：606-613
- 全文大小：350K
- 年卷期：v.78,no.2(January 18, 2013)
- ISSN：1520-6904
文摘
We describe herein a viable binary acid strategy for the catalytic Nazarov reaction of aryl vinyl ketones. Simply combining a Lewis acid and a Br酶nsted acid led to a dramatic enhancement of the catalytic activity in the Nazarov reaction of aryl vinyl 尾-ketoesters. The obtained optimal binary acid catalyst In(OTf)3/diphenyl phosphoric acid (DPP) can be applied to a range of aryl vinyl ketones with good activity. A trend of reactivity has also been summarized on the basis of mapping of the substituents.