Hybrids of Phenylsulfonylfuroxan and Coumarin as Potent Antitumor Agents

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• 作者：Ming-Ming Liu ; Xiao-Yu Chen ; Yao-Qing Huang ; Pan Feng ; Ya-Lan Guo ; Gong Yang ; Ying Chen
• 刊名：Journal of Medicinal Chemistry
• 出版年：2014
• 出版时间：November 26, 2014
• 年：2014
• 卷：57
• 期：22
• 页码：9343-9356
• 全文大小：692K
• ISSN：1520-4804

文摘

Sixteen furoxan-based nitric oxide (NO) releasing coumarin derivatives (6a鈥?b>c, 8a鈥?b>g, 10a, 13a,b, 15, and 17a,b) were designed, synthesized, and evaluated against the A549, HeLa, A2780, A2780/CDDP, and HUVEC cell lines. Most derivatives displayed potent antiproliferation activities. Among them, 8b exhibited the strongest antiproliferation activity on the four sensitive cell lines mentioned above and three drug resistant tumor cell lines A2780/CDDP, MDA-MB-231/Gem, and SKOV3/CDDP with IC₅₀ values from 14 to 53 nM and from 62 to 140 nM, respectively. Furthermore, 8b inhibited the growth of A2780 in vivo and displayed lower toxicity on nontumorigenesis T29, showing good selectivity against malignant cells in vitro. Preliminary pharmacological studies showed that 8b induces apoptosis, arrests the cell cycle at the G2/M phase in the A2780 cell line, and disrupts the phosphorylation of MEK1 and ERK1. Overall, the NO-releasing capacity and the inhibition of ERK/MAPK pathway signaling may explain the potent antineoplastic activity of these compounds.