Chiral (Acyclic Diaminocarbene)Gold(I)-Catalyzed Dynamic Kinetic Asymmetric Transformation of Propargyl Esters
详细信息 查看全文
- 作者：Yi-Ming Wang ; Christian N. Kuzniewski ; Vivek Rauniyar ; Christina Hoong ; F. Dean Toste
- 刊名：Journal of the American Chemical Society
- 出版年：2011
- 出版时间：August 24, 2011
- 年：2011
- 卷：133
- 期：33
- 页码：12972-12975
- 全文大小：762K
- 年卷期：v.133,no.33(August 24, 2011)
- ISSN：1520-5126
文摘
A highly enantioselective transformation catalyzed by chiral (acyclic diaminocarbene)gold(I) complexes is reported. The enantioselective synthesis of 2-substituted chromenyl pivalates from racemic phenol-substituted propargyl pivalates was developed. Rearrangement of the substrates in the presence of cationic gold gave allene intermediates, whose cyclization resulted in formation of enantioenriched product through a dynamic kinetic asymmetric transformation.