Photocontrolled Compound Release System Using Caged Antimicrobial Peptide

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• 作者：Shin Mizukami ; Mariko Hosoda ; Takafumi Satake ; Satoshi Okada ; Yuichiro Hori ; Toshiaki Furuta ; Kazuya Kikuchi
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：July 21, 2010
• 年：2010
• 卷：132
• 期：28
• 页码：9524-9525
• 全文大小：135K
• 年卷期：v.132,no.28(July 21, 2010)
• ISSN：1520-5126

文摘

A novel photocontrolled compound release system using liposomes and a caged antimicrobial peptide was developed. The caged antimicrobial peptide was activated by UV irradiation, resulting in the formation of pores on the liposome surface to release the contained fluorophores. The compound release could be observed using fluorescence measurements and time-lapse fluorescence microscopy. UV irradiation resulted in a quick release of the inclusion compounds (within 1 min in most cases) under simulated physiological conditions. The proposed system is expected to be applicable in a wide range of fields from cell biology to clinical sciences.