Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery

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• 作者：Yevhen Fatieiev ; Jonas G. Croissant ; Shahad Alsaiari ; Basem A. Moosa ; Dalaver H. Anjum ; Niveen M. Khashab
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：November 18, 2015
• 年：2015
• 卷：7
• 期：45
• 页码：24993-24997
• 全文大小：354K
• ISSN：1944-8252

文摘

Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene鈥揳mmonium bridges are described. The systematic screening of the sol鈥揼el parameters allowed the material to reach the nanoscale with controlled dense and hollow structures of 100鈥?00 nm. The hybrid composition of silsesquioxanes with 50% organic content homogeneously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to 鈭?9 mV via a photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such nanoparticles were applied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.