Improved Therapeutic Effect of DOX-PLGA-PEG Micelles Decorated with Bivalent Fragment HAb18 F(ab′)2 for Hepatocellular Carcinoma

详细信息    查看全文

• 作者：Cheng Jin ; Niansong Qian ; Wei Zhao ; Wenqing Yang ; Ling Bai ; Hong Wu ; Minchang Wang ; Wenjie Song ; Kefeng Dou
• 刊名：Biomacromolecules
• 出版年：2010
• 出版时间：September 13, 2010
• 年：2010
• 卷：11
• 期：9
• 页码：2422-2431
• 全文大小：587K
• 年卷期：v.11,no.9(September 13, 2010)
• ISSN：1526-4602

文摘

Although surgery offers the only hope of cure for hepatocellular carcinoma (HCC), patients with inoperable or metastatic disease have a dismal prognosis. Therefore, there is an urgent need for new and effective treatment strategies. Polymeric micelles composed of drug conjugated to a diblock copolymer have attracted great interest for clinical administration of anticancer drugs. In this work, characteristics and cytotoxicity of doxorubicin-poly(d,l-lactic-co-glycolic acid)-poly(ethylene glycol) (DOX-PLGA-PEG) micelle and its targeted micelle decorated with bivalent fragment HAb18 F(ab′)₂ for HCC were studied. These micelles possessed spherical morphology and higher loading efficiency. Cellular uptake and accumulation in tumor tissue of micelles was observed. The accumulation of the targeted micelles depends on dual effects of passive and active targeting. The drug-loading micelles showed cytotoxicity on tumor cells in vitro and in vivo. The targeted micelles resulted in significant improvement in therapeutic response. These results suggest that the novel micelles could be a promising candidate with excellent therapeutic efficacy for targeting the drugs to cancer cells.