De Novo Design of Ln(III) Coiled Coils for Imaging Applications

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• 作者：Matthew R. Berwick ; David J. Lewis ; Andrew W. Jones ; Rosemary A. Parslow ; Timothy R. Dafforn ; Helen J. Cooper ; John Wilkie ; Zoe Pikramenou ; Melanie M. Britton ; Anna F. A. Peacock
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：January 29, 2014
• 年：2014
• 卷：136
• 期：4
• 页码：1166-1169
• 全文大小：242K
• ISSN：1520-5126

文摘

A new peptide sequence (MB1) has been designed which, in the presence of a trivalent lanthanide ion, has been programmed to self-assemble to form a three stranded metallo-coiled coil, Ln(III)(MB1)₃. The binding site has been incorporated into the hydrophobic core using natural amino acids, restricting water access to the lanthanide. The resulting terbium coiled coil displays luminescent properties consistent with a lack of first coordination sphere water molecules. Despite this the gadolinium coiled coil, the first to be reported, displays promising magnetic resonance contrast capabilities.