Highly Efficient Synthesis of a Class of Novel Chiral-Bridged Atropisomeric Monophosphine Ligands via Simple Desymmetrization and Their Applications in Asymmetric Suzuki鈥揗iyaura Coupling Reaction
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- 作者：Shouliang Wang ; Jinjin Li ; Tingting Miao ; Wenhao Wu ; Qing Li ; Yue Zhuang ; Zhongyuan Zhou ; Liqin Qiu
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：April 20, 2012
- 年：2012
- 卷：14
- 期：8
- 页码：1966-1969
- 全文大小：250K
- 年卷期：v.14,no.8(April 20, 2012)
- ISSN：1523-7052
文摘
A series of novel chiral-bridged atropisomeric monophosphine ligands were synthesized via convenient and simple pathways. The prepared ligands, especially for ligand 7d, were found to be highly effective in the Pd-catalyzed Suzuki鈥揗iyaura coupling reaction. The steric hindrance and electronic effect of substrates on the reactivity and enantioselectivity were explored preliminarily.