Synthesis of 2-Sulfenylindenones via One-Pot Tandem Meyer–Schuster Rearrangement and Radical Cyclization of Arylpropynols with Disulfides

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• 作者：Xing-Song Zhang ; Jun-Ying Jiao ; Xiao-Hong Zhang ; Bo-Lun Hu ; Xing-Guo Zhang
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：July 1, 2016
• 年：2016
• 卷：81
• 期：13
• 页码：5710-5716
• 全文大小：402K
• 年卷期：0
• ISSN：1520-6904

文摘

A tandem annulation of arylpropynols with disulfides has been developed for the synthesis of 2-sulfenylindenone derivatives. The reaction pathway involves one-pot tandem Meyer–Schuster rearrangement of arylpropynols and successive radical cyclization with disulfides. Various arylpropynols and disulfides with a number of functional groups are compatible in this reaction that affords the corresponding 2-sulfenylindenones in moderate to good yields.