Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles

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• 作者：Zhiwei Jiao ; Kwok Wei Chee ; Jianrong “Steve” Zhou
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：December 21, 2016
• 年：2016
• 卷：138
• 期：50
• 页码：16240-16243
• 全文大小：445K
• ISSN：1520-5126

文摘

Asymmetric arylation of alkylnitriles forms quaternary stereocenters in good enantiocontrol for the first time. A lithium heterodimer consisting of an alkylnitrile anion and a disilylamide ion is the actual species responsible for the stereodetermining transmetalation in the catalytic cycle.