Palladium-Catalyzed Alkynylation and Concomitant ortho Alkylation of Aryl Iodides

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• 作者：Chuanhu Lei ; Xiaojia Jin ; Jianrong (Steve) Zhou
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：March 4, 2016
• 年：2016
• 卷：6
• 期：3
• 页码：1635-1639
• 全文大小：409K
• ISSN：2155-5435

文摘

We report an efficient alkynylation reaction of aryl iodides with simultaneous ortho-alkylaton of aryl rings. The reaction between three simple reagents—aryl halides, alkynes, and alkyl halides—formed aryl–alkynyl bonds carrying hindered aryl rings in one step. The reaction proceeded via a Catellani-type pathway in the presence of norbornene. From a synthetic perspective, this reaction allows quick access toward many 1,2,3-substituted arenes and multiply substituted benzofurans, after manipulation of alkyne groups. These compounds are difficult to synthesize otherwise.