Preparation of Water-Soluble Hyperbranched Polyester Nanoparticles with Sulfonic Acid Functional Groups and Their Micelles Behavior, Anticoagulant Effect and Cytotoxicity

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• 作者：Qiaorong Han ; Xiaohan Chen ; Yanlian Niu ; Bo Zhao ; Bingxiang Wang ; Chun Mao ; Libin Chen ; Jian Shen
• 刊名：Langmuir
• 出版年：2013
• 出版时间：July 2, 2013
• 年：2013
• 卷：29
• 期：26
• 页码：8402-8409
• 全文大小：362K
• 年卷期：v.29,no.26(July 2, 2013)
• ISSN：1520-5827

文摘

Biocompatibility of nanoparticles has been attracting great interest in the development of nanoscience and nanotechnology. Herein, the aliphatic water-soluble hyperbranched polyester nanoparticles with sulfonic acid functional groups (HBPE-SO₃ NPs) were synthesized and characterized. They are amphiphilic polymeric nanoparticles with hydrophobic hyperbranched polyester (HBPE) core and hydrophilic sulfonic acid terminal groups. Based on our observations, we believe there are two forms of HBPE-SO₃ NPs in water under different conditions: unimolecular micelles and large multimolecular micelles. The biocompatibility and anticoagulant effect of the HBPE-SO₃ NPs were investigated using coagulation tests, hemolysis assay, morphological changes of red blood cells (RBCs), complement and platelet activation detection, and cytotoxicity (MTT). The results confirmed that the sulfonic acid terminal groups can substantially enhance the anticoagulant property of HBPE, and the HBPE-SO₃ NPs have the potential to be used in nanomedicine due to their good bioproperties.