Withanolides from Physalis hispida
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- 作者：Cong-Mei Cao ; Huaping Zhang ; Robert J. Gallagher ; Victor W. Day ; Kelly Kindscher ; Patrick Grogan ; Mark S. Cohen ; Barbara N. Timmermann
- 刊名：Journal of Natural Products
- 出版年：2014
- 出版时间：March 28, 2014
- 年：2014
- 卷：77
- 期：3
- 页码：631-639
- 全文大小：332K
- 年卷期：v.77,no.3(March 28, 2014)
- ISSN：1520-6025
文摘
Nine new withanolides (1鈥?b>9), withahisolides A鈥揑, were isolated along with nine known compounds (10鈥?b>18) from the aerial parts of Physalis hispida. The structures of 1鈥?b>9 were elucidated through a variety of spectroscopic techniques, while the structures of 1 and 2 were confirmed by X-ray crystallographic analysis. Compounds 1鈥?b>3 are the first withanolides with nonaromatic six-membered ring D moieties. In addition, withanolide 8 represents a novel withanolide skeleton due to the absence of a C-13鈥揅-17 bond within the steroidal nucleus.