Aliphatic Phenolic Ethers from Trichobotrys effusa

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• 作者：Jih-Jung Chen ; Shih-Wei Wang ; Hui-Yun Hsiao ; Ming-Shian Lee ; Yu-Min Ju ; Yueh-Hsiung Kuo ; Tzong-Huei Lee
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：May 23, 2014
• 年：2014
• 卷：77
• 期：5
• 页码：1097-1101
• 全文大小：257K
• 年卷期：v.77,no.5(May 23, 2014)
• ISSN：1520-6025

文摘

Four novel aliphatic phenolic ethers, namely, trichoethers A鈥揇 (1鈥?b>4), possessing a unique C₁₁鈥揙鈥揅₁₀ skeleton, together with coriloxin, zythiostromic acid A, radicicol, and 3,5-dihydroxytoluene were isolated from the ethyl acetate extracts of the fermented broths of Trichobotrys effusa YMJ1179. The structures of all the compounds were determined based on spectroscopic data analysis. The configurations of 1鈥?b>4 were established by J values and NOESY and compared with published data. Compounds 1鈥?b>4 and radicicol exhibited growth-inhibitory activities against the A549 non-small-cell lung cancer cell line with GI₅₀ values of 25.61, 19.32, 16.19, 24.31, and 1.43 渭M, respectively, in comparison with 5-fluorouracil (GI₅₀ = 4.55 渭M).