Selective Hydrolysis of Phosphate Monoester by a Supramolecular Phosphatase Formed by the Self-Assembly of a Bis(Zn2+-cyclen) Complex, Cyanuric Acid, and Copper in an Aqueous Solution (Cycl

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• 作者：Mohd Zulkefeli ; Asami Suzuki ; Motoo Shiro ; Yosuke Hisamatsu ; Eiichi Kimura ; Shin Aoki
• 刊名：Inorganic Chemistry
• 出版年：2011
• 出版时间：October 17, 2011
• 年：2011
• 卷：50
• 期：20
• 页码：10113-10123
• 全文大小：1229K
• 年卷期：v.50,no.20(October 17, 2011)
• ISSN：1520-510X

文摘

In Nature, organized nanoscale structures such as proteins and enzymes are formed in aqueous media via intermolecular interactions between multicomponents. Supramolecular and self-assembling strategies provide versatile methods for the construction of artificial chemical architectures for controlling reaction rates and the specificities of chemical reactions, but most are designed in hydrophobic environments. The preparation of artificial catalysts that have potential in aqueous media mimicking natural enzymes such as hydrolases remains a great challenge in the fields of supramolecular chemistry. Herein, we describe that a dimeric Zn²⁺ complex having a 2,2鈥?bipyridyl linker, cyanuric acid, and a Cu²⁺ ion automatically assembles in an aqueous solution to form a 4:4:4 complex, which is stabilized by metal鈥搇igand coordination bonds, 蟺鈥撓€-stacking interactions, and hydrogen bonding and contains 渭-Cu₂(OH)₂ cores analogous to the catalytic centers of phosphatase, a dinuclear metalloenzyme. The 4:4:4 complex selectively accelerates the hydrolysis of a phosphate monoester, mono(4-nitrophenyl)phosphate, at neutral pH.