Enzymatic Degradation of Supramolecular Materials Based on Partial Inclusion Complex Formation between α-Cyclodextrin and Poly(ε-caprolactone)

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• 作者：Haiya Luo ; Xianwei Meng ; Cong Cheng ; Zhenqiang Dong ; Sheng Zhang ; Bangjing Li
• 刊名：Journal of Physical Chemistry B
• 出版年：2010
• 出版时间：April 8, 2010
• 年：2010
• 卷：114
• 期：13
• 页码：4739-4745
• 全文大小：417K
• 年卷期：v.114,no.13(April 8, 2010)
• ISSN：1520-5207

文摘

Supramolecular biomaterials were prepared based on the formation of partial inclusion complexes between α-CD and poly(ε-caprolactone) (PCL). Enzyme-catalyzed degradation of these partial α-CD−PCL inclusion complexes was investigated at 37 °C in the presence of lipase from pancreas porcine. The biodegradation behaviors were monitored by weight loss measurement, ¹H NMR, XRD, GPC, DSC, and SEM. It was found that the formation of inclusion segments significantly accelerated the degradation of materials. A mechanism of enzymatic degradation for partial α-CD−PCL inclusion complexes was proposed. The present study provides a preliminary understanding for the biodegradation of the materials constructed by self-assembly between cyclodextrin and polymers.