Biocompatible Nanoparticles of KGd(H2O)2[Fe(CN)6]路H2O with Extremely High T1-Weighted Relaxivity Owing to Two Water Molecules Directly Bou

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• 作者：Vindya S. Perera ; Liu D. Yang ; Jihua Hao ; Guojun Chen ; Bernadette O. Erokwu ; Chris A. Flask ; Peter Y. Zavalij ; James P. Basilion ; Songping D. Huang
• 刊名：Langmuir
• 出版年：2014
• 出版时间：October 14, 2014
• 年：2014
• 卷：30
• 期：40
• 页码：12018-12026
• 全文大小：425K
• ISSN：1520-5827

文摘

A simple one-step method for preparing biocompatible nanoparticles of gadolinium ferrocyanide coordination polymer KGd(H₂O)₂[Fe(CN)₆]路H₂O is reported. The crystal structure of this coordination polymer is determined by X-ray powder diffraction using the bulk materials. The stability, cytotoxicity, cellular uptake, and MR phantom and cellular imaging studies suggest that this coordination-polymer structural platform offers a unique opportunity for developing the next generation of T₁-weighted contrast agents with high relaxivity as cellular MR probes for biological receptors or markers. Such high-relaxivity MR probes may hold potential in the study of molecular events and may be used for in vivo MR imaging in biomedical research and clinical applications.