Controlled Release and Assembly of Drug Nanoparticles via pH-Responsive Polymeric Micelles: A Theoretical Study

详细信息    查看全文

• 作者：Guang-Kui Xu ; Xi-Qiao Feng ; Bo Li ; Huajian Gao
• 刊名：The Journal of Physical Chemistry B
• 出版年：2012
• 出版时间：May 24, 2012
• 年：2012
• 卷：116
• 期：20
• 页码：6003-6009
• 全文大小：376K
• 年卷期：v.116,no.20(May 24, 2012)
• ISSN：1520-5207

文摘

Tumor tissues often have a pH value lower than normal tissues, and this difference suggests a promising way of targeted cancer therapy by using pH-controlled drug delivery systems. On the basis of the mean-field theory, we present a theoretical methodology to predict the self-assembly and disassembly of pH-responsive polymers and nanoparticles in an ionic solution. It is found that vesicles, cylindrical, and spherical micelles can rapidly disassemble and release contained nanoparticles in a narrow pH range. The model is further used to study the controlled assembly of pH-sensitive drug with significantly improved encapsulation efficiency. This method is also applicable for the design of controlled delivery nanodevices for various biomedical applications.