Copper-Catalyzed Complete Regio- and Stereoselective Cyclization of 1-Aryl-3-sulfanyl-4-oxahepta-1,6-diynes Triggered by Alkynylation

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• 作者：Mitsuhiro Yoshimatsu ; Hitomi Sasaki ; Yuko Sugimoto ; Yuya Nagase ; Genzoh Tanabe ; Osamu Muraoka
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：June 15, 2012
• 年：2012
• 卷：14
• 期：12
• 页码：3190-3193
• 全文大小：265K
• 年卷期：v.14,no.12(June 15, 2012)
• ISSN：1523-7052

文摘

Copper(I)-catalyzed alkynylation鈥揷yclization of 4-oxahepta-1,6-diynes 1 with a wide variety of terminal alkynes proceeded to give (3E,4Z)-3-(phenylsulfanylmethylene)-4-(2-propynylidene)tetrahydrofuran-2-yl]benzenes 2aa鈥?b>he in high yields with complete regio- and stereoselectivity.