A Solid Phase Reagent for the Capture Phosphorylation of Carbohydrates and Nucleosides

详细信息    查看全文

• 作者：Keykavous Parang ; Eric J.-L. Fournier ; and Ole Hindsgaul
• 刊名：Organic Letters
• 出版年：2001
• 出版时间：January 25, 2001
• 年：2001
• 卷：3
• 期：2
• 页码：307 - 309
• 全文大小：40K
• 年卷期：v.3,no.2(January 25, 2001)
• ISSN：1523-7052

文摘

D>A 1% cross-linked divinylbenzene-polystyrene copolymer, containing cyanoethoxy N,N-diisopropylamine phosphine was prepared as aphosphitylating agent. The polymer-bound phosphitylated precursor was subjected to reaction with alcohols in the presence of 1H-tetrazoleto produce the corresponding polymer-bound phosphite triesters. These were then oxidized with tert-butyl hydroperoxide to give the polymer-bound monophosphate triesters. Removal of cyanoethoxy on the resin with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) followed by basic cleavageof the p-hydroxybenzyl linker products yielded monophosphate derivatives.

---