Cyanidin-3-O-尾-glucoside Purified from Black Rice Protects Mice against Hepatic Fibrosis Induced by Carbon Tetrachloride via Inhibiting Hepatic Stellate Cell Activation

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• 作者：Xinwei Jiang ; Honghui Guo ; Tianran Shen ; Xilan Tang ; Yan Yang ; Wenhua Ling
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2015
• 出版时间：July 15, 2015
• 年：2015
• 卷：63
• 期：27
• 页码：6221-6230
• 全文大小：589K
• ISSN：1520-5118

文摘

This study investigated whether cyanidin-3-O-尾-glucoside (Cy-3-G), a predominant anthocyanin, could exert a protective role on liver injury and its further mechanisms of the anti-fibrosis actions in mice. The results demonstrated that the treatment of Cy-3-G (800 mg/kg diet) for 8 weeks significantly attenuated hepatotoxicity and fibrosis in carbon tetrachloride (CCl₄) administered mice. Cy-3-G strongly down-regulated the expression of 伪-smooth muscle actin (伪-SMA), desmin, and matrix metalloproteinase (MMPs), which showed its suppression effect on the activation of hepatic stellate cells (HSCs). In addition, Cy-3-G favorably regulated oxidative stress and apoptosis in liver. Furthermore, Cy-3-G ameliorated the infiltration of inflammatory cells such as neutrophils and leukocytes and meanwhile suppressed the production of pro-inflammatory cytokines and growth factors. In conclusion, daily intake of Cy-3-G could prevent liver fibrosis progression in mice induced by CCl₄ through inhibiting HSC activation, which provides a basis for clinical practice of liver fibrosis prevention.