Copper-Catalyzed Desymmetric Intramolecular Ullmann C鈥揘 Coupling: An Enantioselective Preparation of Indolines

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• 作者：Fengtao Zhou ; Jiajia Guo ; Jianguang Liu ; Ke Ding ; Shouyun Yu ; Qian Cai
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：September 5, 2012
• 年：2012
• 卷：134
• 期：35
• 页码：14326-14329
• 全文大小：301K
• 年卷期：v.134,no.35(September 5, 2012)
• ISSN：1520-5126

文摘

The first highly enantioselective copper-catalyzed intramolecular Ullmann C鈥揘 coupling reaction has been developed. The asymmetric desymmetrization of 1,3-bis(2-iodoaryl)propan-2-amines catalyzed by CuI/(R)-BINOL-derived ligands led to the enantioselective formation of indolines in high yields and excellent enantiomeric excesses. This method was also applied to the formation of 1,2,3,4-tetrahydroquinolines in high yields and excellent enantioselectivity.