A Versatile, Traceless C–H Activation-Based Approach for the Synthesis of Heterocycles

详细信息    查看全文

• 作者：Shuguang Zhou ; Jinhu Wang ; Feifei Zhang ; Chao Song ; Jin Zhu
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：May 20, 2016
• 年：2016
• 卷：18
• 期：10
• 页码：2427-2430
• 全文大小：398K
• 年卷期：0
• ISSN：1523-7052

文摘

A versatile, traceless C–H activation-based approach for the synthesis of diversified heterocycles is reported. Rh(III)-catalyzed, N-amino-directed C–H alkenylation generates either olefination products or indoles (in situ annulation) in an atom- and step-economic manner at room temperature. The remarkable reactivity endowed by this directing group enables scale-up of the reaction to a 10 g scale at a very low catalyst loading (0.01 mol %/0.1 mol %). Ex situ annulation of olefination product provides entry into an array of heterocycles.