Phosphoiodyns A and B, Unique Phosphorus-Containing Iodinated Polyacetylenes from a Korean Sponge Placospongia sp.

详细信息    查看全文

• 作者：Hiyoung Kim ; Jungwook Chin ; Hyukjae Choi ; Kyungryul Baek ; Tae-Gu Lee ; Seong Eon Park ; Weihong Wang ; Dongyup Hahn ; Inho Yang ; Jihye Lee ; Bora Mun ; Merrick Ekins ; Sang-Jip Nam ; Heonjoong Kang
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：January 4, 2013
• 年：2013
• 卷：15
• 期：1
• 页码：100-103
• 全文大小：200K
• 年卷期：v.15,no.1(January 4, 2013)
• ISSN：1523-7052

文摘

Two unprecedented phosphorus-containing iodinated polyacetylenes, phosphoiodyns A and B (1鈥?b>2), were isolated from a Korean marine sponge Placospongia sp. Their structures were elucidated by spectroscopic data analysis. Phosphoiodyn A exhibited potent agonistic activity on human peroxisome proliferator-activated receptor delta (hPPAR未) with an EC₅₀ of 23.7 nM.