The Preparation of Colloidally Stable, Water-Soluble, Biocompatible, Semiconductor Nanocrystals with a Small Hydrodynamic Diameter

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• 作者：Emma E. Lees ; Tich-Lam Nguyen ; Andrew H. A. Clayton ; Paul Mulvaney
• 刊名：ACS Nano
• 出版年：2009
• 出版时间：May 26, 2009
• 年：2009
• 卷：3
• 期：5
• 页码：1121-1128
• 全文大小：408K
• 年卷期：0
• ISSN：1936-086X

文摘

We report a simple, economical method for generating water-soluble, biocompatible nanocrystals that are colloidally robust and have a small hydrodynamic diameter. The nanocrystal phase transfer technique utilizes a low molecular weight amphiphilic polymer that is formed via maleic anhydride coupling of poly(styrene-co-maleic anhydride) with either ethanolamine or Jeffamine M-1000 polyetheramine. The polymer encapsulated water-soluble nanocrystals exhibit the same optical spectra as those formed initially in organic solvents, preserve photoluminescence intensities, are colloidally stable over a wide pH range (pH 3−13), have a small hydrodynamic diameter, and exhibit low levels of nonspecific binding to cells.