Multifunctional Polyelectrolyte Multilayer Films: Combining Mechanical Resistance, Biodegradability, and Bioactivity

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• 作者：Aurore Schneider ; Constant Vodouhê ; Ludovic Richert ; Gregory Francius ; Erell Le Guen ; Pierre Schaaf ; Jean-Claude Voegel ; Benoî ; t Frisch ; Catherine Picart
• 刊名：Biomacromolecules
• 出版年：2007
• 出版时间：January 2007
• 年：2007
• 卷：8
• 期：1
• 页码：139 - 145
• 全文大小：176K
• 年卷期：v.8,no.1(January 2007)
• ISSN：1526-4602

文摘

Cross-linked polyelectrolyte multilayer films (CL PEM) have an increased rigidity and are mechanically moreresistant than native (e.g., uncrosslinked) films. However, they are still biodegradable, which make them interestingcandidates for biomedical applications. In this study, CL PEM films have been explored for their multifunctionalproperties as (i) mechanically resistant, (ii) biodegradable, and (iii) bioactive films. Toward this end, we investigateddrug loading into CL chitosan/hyaluronan (CHI/HA) and poly(L-lysine)/hyaluronan (PLL/HA) films by simplediffusion of the drugs. Sodium diclofenac and paclitaxel were chosen as model drugs and were successfullyloaded into the films. The effect of varying the number of layers in the (CHI/HA) films as well as the cross-linkerconcentration on diclofenac loading were studied. Diclofenac was released from the film in about 10 h. Paclitaxelwas also found to diffuse within CL films. Its activity was maintained after loading in the CL films, and cellularviability could be reduced by about 55% over 3 days. Such a simple approach may be applied to other types ofcross-linked films and to other drugs. These results prove that it is possible to design multifunctional multilayerfilms that combine mechanical resistance, biodegradability, and bioactivity properties into a single PEM architecture.