Synthesis and pH-Responsive 鈥淪chizophrenic鈥?Aggregation of a Linear-Dendron-Like Polyampholyte Based on Oppositely Charged Polypeptides

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• 作者：Lili Chen ; Tao Chen ; Wenxiang Fang ; Ying Wen ; Shaoliang Lin ; Jiaping Lin ; Chunhua Cai
• 刊名：Biomacromolecules
• 出版年：2013
• 出版时间：December 9, 2013
• 年：2013
• 卷：14
• 期：12
• 页码：4320-4330
• 全文大小：556K
• 年卷期：v.14,no.12(December 9, 2013)
• ISSN：1526-4602

文摘

A novel linear-dendron-like polyampholyte, poly(l-lysine)-b-D2-poly(l-glutamic acid) [PLL-b-D2-(PLGA)₄], where D2 is the second generation of poly(amido amine), was prepared by hydrolyzing poly(蔚-benzyloxycarbonyl-l-lysine)-b-D2-poly(纬-benzyl-l-glutamate) copolymer which was synthesized via a combination of ring-opening polymerization and click chemistry. The pH-responsive self-assembly behaviors of PLL-b-D2-(PLGA)₄ were investigated in detail. It is found that PLL-b-D2-(PLGA)₄ can self-assemble into PLGA-core aggregates at acidic pH and PLL-core aggregates at alkaline pH, which was accompanied with the coil-to-helix conformational transition of PLGA and PLL segments, respectively. The self-assembled aggregates with various morphologies, such as large compound micelles, worm-like micelles, large compound vesicles, simple vesicles, and rigid tubular structures have been obtained in 鈥渟chizophrenic鈥?aggregation process with simply increasing the solution pH. The hierarchical assembled fractal structures of PLL-b-D2-(PLGA)₄ were observed during the solvent evaporation at high pH value.