Palladium-Catalyzed Decarboxylative Cross-Coupling Reaction Between Heteroaromatic Carboxylic Acids and Aryl Halides
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- 作者：Franois Bilodeau ; Marie-Christine Brochu ; Nicolas Guimond ; Kris H. Thesen ; Pat Forgione
- 刊名：Journal of Organic Chemistry
- 出版年：2010
- 出版时间：March 5, 2010
- 年：2010
- 卷：75
- 期：5
- 页码：1550-1560
- 全文大小：1017K
- 年卷期：v.75,no.5(March 5, 2010)
- ISSN：1520-6904
文摘
A full overview of the decarboxylative cross-coupling reaction between heteroaromatic carboxylic acids and aryl halides is described. This transformation employs palladium catalysts with short reaction times providing facile synthesis of aryl-substituted heteroaromatics. The effect of each reaction parameter including solvent, base, and additive employed as well as the full substrate scope of this transformation are reported. Mechanistic evidence is also disclosed that sheds light on possible reaction pathways.