Tirucallane Triterpenoids from Cornus walteri

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• 作者：Ki Hyun Kim ; Sang Un Choi ; Young Choong Kim ; Kang Ro Lee
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：January 28, 2011
• 年：2011
• 卷：74
• 期：1
• 页码：54-59
• 全文大小：160K
• 年卷期：v.74,no.1(January 28, 2011)
• ISSN：1520-6025

文摘

Twelve new tirucallane triterpenoids, named cornusalterins A鈭扡 (1鈭?b>12), and two known tirucallane triterpenoids, deoxyflindissone (13) and (鈭?-leucophyllone (14), were isolated from a MeOH extract of stems and stem bark of Cornus walteri. The structures of the new compounds were determined by spectroscopic methods, including 1D and 2D NMR analyses. Compounds 12 and 13, possessing a tetrahydrofuran ring in the side chain, exhibited significant cytotoxic activity against the A549, SK-OV-3, SK-MEL-2, and XF498 cell lines.