The Effect of Curcumin on the Stability of A尾 Dimers

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• 作者：Li Na Zhao ; See-Wing Chiu ; J茅r么me Benoit ; Lock Yue Chew ; Yuguang Mu
• 刊名：The Journal of Physical Chemistry B
• 出版年：2012
• 出版时间：June 28, 2012
• 年：2012
• 卷：116
• 期：25
• 页码：7428-7435
• 全文大小：503K
• 年卷期：v.116,no.25(June 28, 2012)
• ISSN：1520-5207

文摘

A尾 oligomers are potential targets for the diagnosis and therapy of Alzheimer鈥檚 disease (AD). On the other hand, the molecule curcumin has been shown to possess significant therapeutic potential in many areas. In this paper, we use all-atom explicit solvent molecular dynamics simulations to study the effect of curcumin on the stability of A尾 amyloid protein oligomers. We observed that curcumin decreases the 尾-sheet secondary structural content within the A尾 oligomers without reducing the contacts between the monomers. The breaking of the 尾-sheet is found to be preceded by a deformation of the 尾-sheet structure due to hydrophobic interaction from the nearby curcumin. Furthermore, the 蟺-stacking interaction between curcumin (keto ring and enol ring) and the aromatic residues of A尾, which exists throughout the simulations, has also contributed to the diminishing of the 尾-sheet structure. Our analysis of the underwrapped amide鈥揷arbonyl hydrogen bonds reveals several stable dehydrons of the oligomer, especially the dehydron pair 34L and 41I, which curcumin tends to hover over. We have examined the paths of curcumin on the A尾 proteins and determined the common routes where curcumin lingers as it traverses around the A尾. In consequence, our study has provided a detailed interaction picture between curcumin and the A尾 oligomers.