Anti-Inflammatory Spirostanol and Furostanol Saponins from Solanum macaonense

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• 作者：Chia-Lin Lee ; Tsong-Long Hwang ; Juan-Cheng Yang ; Hao-Ting Cheng ; Wan-Jung He ; Chiao-Ting Yen ; Chao-Lin Kuo ; Chao-Jung Chen ; Wen-Yi Chang ; Yang-Chang Wu
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：August 22, 2014
• 年：2014
• 卷：77
• 期：8
• 页码：1770-1783
• 全文大小：560K
• ISSN：1520-6025

文摘

Eight new spirostanol saponins, macaosides A鈥揌 (1鈥?b>8), and 10 new furostanol saponins, macaosides I鈥揜 (9鈥?b>18), together with six known spirostanol compounds (19鈥?b>24) were isolated from Solanum macaonense. The structures of the new compounds were determined from their spectroscopic data, and the compounds were tested for in vitro antineutrophilic inflammatory activity. It was found that both immediate inflammation responses including superoxide anion generation and elastase release were significantly inhibited by treatment with compounds 20, 21, and 24 (superoxide anion generation: IC₅₀ 7.0, 7.6, 4.0 渭M; elastase release: IC₅₀ 3.7, 4.4, 1.0 渭M, respectively). However, compounds 1 and 4 exhibited effects on the inhibition of elastase release only, with IC₅₀ values of 3.2 and 4.2 渭M, respectively, while 19 was active against superoxide anion generation only, with an IC₅₀ value of 6.1 渭M. Accordingly, spirostanols may be promising lead compounds for further neutrophilic inflammatory disease studies.