Supramolecular Assembly Mediates the Formation of Single-Chain Polymeric Nanoparticles

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• 作者：Chih-Chia Cheng ; Feng-Chih Chang ; Hsiu-Che Yen ; Duu-Jong Lee ; Chih-Wei Chiu ; Zhong Xin
• 刊名：ACS Macro Letters
• 出版年：2015
• 出版时间：October 20, 2015
• 年：2015
• 卷：4
• 期：10
• 页码：1184-1188
• 全文大小：383K
• ISSN：2161-1653

文摘

A breakthrough innovation in water-based polymeric nanoparticles has enabled significant progress in mimicking the folding of natural proteins by generating novel 鈥渟ingle-chain polymeric nanoparticles鈥?(SCPNs) via supramolecular interactions. In this study, a practical approach to the living polymerization of functionalized oligo(ethylene glycol) methacrylate monomers allows the incorporation of self-constituted multiple hydrogen-bonded groups into physically cross-linked polymer networks, which enables the formation of highly functionalized SCPNs in an aqueous environment. The newly developed materials are particularly attractive from a practical point of view since they have a very low critical micellization concentration and uniform particle diameters of ca. 25 nm, making them extremely stable under dilute conditions. Concentration-dependent experiments showed that SCPNs formed at polymer concentrations up to 40 mg/mL with no significant change in morphology observed. Moreover, the formed SCPNs had a very high stability in an aqueous solution containing surfactant, suggesting potential for a wide variety of applications as a promising candidate nanocarrier for bioimaging, controlled release, and drug delivery systems.