Cembrane Diterpenes from the Gorgonian Lophogorgia peruana

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• 作者：M. Carmen Sá ; nchez ; Marí ; a J. Ortega ; Eva Zubí ; a ; J. Luis Carballo
• 刊名：Journal of Natural Products
• 出版年：2006
• 出版时间：December 2006
• 年：2006
• 卷：69
• 期：12
• 页码：1749 - 1755
• 全文大小：192K
• 年卷期：v.69,no.12(December 2006)
• ISSN：1520-6025

文摘

The chemical study of the gorgonian Lophogorgia peruana collected at the Gulf of California has led to the isolationof the new diterpenes lophodienone (2), lophodiol A (3), lophodiol B (4), 17-acetoxylophotoxin (5), 15,16-epoxylophotoxin(6), 17-acetoxy-15,16-epoxylophotoxin (7), and isoepoxylophodione (8), together with the known compounds lophotoxin(1), rubifolide (9), lopholide (10), deoxylophotoxin (11), and the lophotoxin analogues 12 and 13. The structures of thenew metabolites have been established by spectroscopic techniques and chemical correlation. The in vitro cytotoxicityhas been tested against three tumor cell lines.