文摘
The preparation of small focused libraries of supported catalysts and reagents represents anintermediate approach lying between combinatorial and single-compound methodologies. In thiscase, the potential structural variations can be selected according to previous studies in solution,to limit, to a reasonable extent, the number of components of the library. In our case, we haveapplied this strategy to the optimization of the structure of supported chiral amino alcohols fortheir use in catalytic processes (addition of ZnEt2 to benzaldehyde) as well as in noncatalyticreactions (lithium aluminum hydride reduction of acetophenone). This approach allows takinginto consideration simultaneously both the structural variations on the chiral unit and the roleof the support.