Controlling Electron Trap Depth To Enhance Optical Properties of Persistent Luminescence Nanoparticles for In Vivo Imaging

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• 作者：Thomas Maldiney ; Aur茅lie Lecointre ; Bruno Viana ; Aur茅lie Bessi猫re ; Michel Bessodes ; Didier Gourier ; Cyrille Richard ; Daniel Scherman
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：August 3, 2011
• 年：2011
• 卷：133
• 期：30
• 页码：11810-11815
• 全文大小：847K
• 年卷期：v.133,no.30(August 3, 2011)
• ISSN：1520-5126

文摘

Focusing on the use of nanophosphors for in vivo imaging and diagnosis applications, we used thermally stimulated luminescence (TSL) measurements to study the influence of trivalent lanthanide Ln³⁺ (Ln = Dy, Pr, Ce, Nd) electron traps on the optical properties of Mn²⁺-doped diopside-based persistent luminescence nanoparticles. This work reveals that Pr³⁺ is the most suitable Ln³⁺ electron trap in the diopside lattice, providing optimal trap depth for room temperature afterglow and resulting in the most intense luminescence decay curve after X-ray irradiation. This luminescence dependency toward the electron trap is maintained through additional doping with Eu²⁺, allowing UV-light excitation, critical for bioimaging applications in living animals. We finally identify a novel composition (CaMgSi₂O₆:Eu²⁺,Mn²⁺,Pr³⁺) for in vivo imaging, displaying a strong near-infrared afterglow centered on 685 nm, and present evidence that intravenous injection of such persistent luminescence nanoparticles in mice allows not only improved but highly sensitive detection through living tissues.