6-Trifluoromethylpyridoxine: Novel 19F NMR pH Indicator for in Vivo Detection

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• 作者：Jian-Xin Yu ; Weina Cui ; Vincent A. Bourke ; Ralph P. Mason
• 刊名：Journal of Medicinal Chemistry
• 出版年：2012
• 出版时间：August 9, 2012
• 年：2012
• 卷：55
• 期：15
• 页码：6814-6821
• 全文大小：347K
• 年卷期：v.55,no.15(August 9, 2012)
• ISSN：1520-4804

文摘

pH plays an important role in tumor proliferation, angiogenesis, metabolic control, and the efficacy of cytotoxic therapy, and accurate noninvasive assessment of tumor pH promises to provide insight into developmental processes and prognostic information. In this paper, we report the design, synthesis, and characterization of two novel pH indicators 6-trifluoromethylpyridoxine 8 and 伪⁴,伪⁵-di-O-[3鈥?O-(尾-an class="smallcaps">dan>-glucopyranosyl)propyl]-6-trifluoromethylpyridoxine 17 and demonstrate 8 as an extracellular ¹⁹F NMR pH probe to assess pH_e of various tumors in vivo.