Bu4NI Catalyzed C鈥揘 Bond Formation via Cross-Dehydrogenative Coupling of Aryl Ethers (Csp3鈥揌) and Tetrazoles (N鈥揌)

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• 作者：Suresh Rajamanickam ; Ganesh Majji ; Sourav Kumar Santra ; Bhisma K. Patel
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：November 20, 2015
• 年：2015
• 卷：17
• 期：22
• 页码：5586-5589
• 全文大小：380K
• ISSN：1523-7052

文摘

Intermolecular C鈥揘 bond formations via cross-dehydrogenative coupling (CDC) of aryl ethers and tetrazoles have been developed under a metal-free condition. In the presence of catalytic amount of tetrabutylammonium iodide (TBAI) and aqueous TBHP, aryl ethers coupled efficiently with tetrazoles to afford hemiaminal ethers. This strategy showed high level of regioselectivity for substrates possessing multiple sp³ C鈥揌 bonds adjacent to the ethereal oxygen.