Synthesis and Characterization of Dye-Labeled Poly(methacrylic acid) Grafted Silica Nanoparticles

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• 作者：Lei Wang ; Brian C. Benicewicz
• 刊名：ACS Macro Letters
• 出版年：2013
• 出版时间：February 19, 2013
• 年：2013
• 卷：2
• 期：2
• 页码：173-176
• 全文大小：252K
• 年卷期：v.2,no.2(February 19, 2013)
• ISSN：2161-1653

文摘

The synthesis of dye-labeled poly(methacrylic acid) (PMAA) grafted silica nanoparticles was studied. Surface-initiated reversible addition鈥揻ragmentation chain transfer (RAFT) polymerization of tert-butylmethacrylate (tBuMA) was conducted on dye-labeled CPDB coated silica nanoparticles followed by sequential removal of the thiocarbonylthio end groups and the tert-butyl moieties. Additionally, as a more straightforward strategy, direct polymerization of methacrylic acid on silica nanoparticles with a diameter size as small as 15 nm was conducted via the RAFT polymerization technique. A variety of PMAA brushes with different lengths and densities were prepared on nanoparticle surfaces via surface-initiated RAFT polymerization with excellent control and surface grafting densities as high as 0.65 chains/nm². The grafted PMAA was methylated by trimethylsilyldiazomethane to conduct organic phase GPC characterization. The dye-labeled PMAA grafted nanoparticles provide a platform to bind biomolecules and to track the movement of the nanoparticles in biological systems.