Light-Induced Isomerization of Apoptolidin A leads to Inversion of C2−C3 Double Bond Geometry

详细信息    查看全文

• 作者：Brian O. Bachmann ; Ruth McNees ; Bruce J. Melancon ; Victor P. Ghidu ; Rachel Clark ; Brenda C. Crews ; Sean M. DeGuire ; Lawrence J. Marnett ; Gary A. Sulikowski
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：July 2, 2010
• 年：2010
• 卷：12
• 期：13
• 页码：2944-2947
• 全文大小：166K
• 年卷期：v.12,no.13(July 2, 2010)
• ISSN：1523-7052

文摘

The isolation, characterization, and cytotoxicity against H292 cells of apoptolidin G are reported. Apoptolidin G is shown to be derived by a light-induced isomerization of the C2−C3 carbon−carbon double bond of apoptolidin A.