A Direct Approach to a 6-Hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine Library

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• 作者：Nadezhda V. Palysaeva ; Katerina P. Kumpan ; Marina I. Struchkova ; Igor L. Dalinger ; Aleksandr V. Kormanov ; Nataly S. Aleksandrova ; Victor M. Chernyshev ; Dmitrii F. Pyreu ; Kyrill Yu. Suponitsky ; Aleksei B. Sheremetev
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：January 17, 2014
• 年：2014
• 卷：16
• 期：2
• 页码：406-409
• 全文大小：313K
• ISSN：1523-7052

文摘

The synthesis of 6-hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines is reported. The functionalized secondary amines were constructed via a K₂CO₃-mediated S_NAr reaction of weakly basic hetarylamines with 3-(3,5-dimethylpyrazol-1-yl)[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines, which allowed displacement 3,5-dimethylpyrazolyl leaving group. Significantly, the reaction exhibited a broad substrate scope and proceeded in good yields.