Development of N,O-(Carboxymethyl)chitosan/Collagen Matrixes as a Wound Dressing

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• 作者：Ray-Neng Chen ; Gen-Ming Wang ; Chien-Ho Chen ; Hsiu-O Ho ; and Ming-Thau Sheu
• 刊名：Biomacromolecules
• 出版年：2006
• 出版时间：April 2006
• 年：2006
• 卷：7
• 期：4
• 页码：1058 - 1064
• 全文大小：1194K
• 年卷期：v.7,no.4(April 2006)
• ISSN：1526-4602

文摘

In an attempt to accelerate wound healing by stimulating the recruitment of fibroblasts and improve the mechanicalproperties of collagen matrixes, N,O-(carboxymethyl)chitosan (NOCC) was incorporated into the backbone of acollagen (COL) matrix without or with chondroitin sulfate (CS) or an acellular dermal matrix (ADM). The resultof a cell migration study demonstrated that the migration of fibroblasts was significantly enhanced by NOCC ina concentration-dependent manner. In the analysis with a dynamic mechanical analyzer, NOCC/CS/COL matrixespresented higher tensile strengths than did NOCC/ADM/COL matrixes. Skin fibroblasts cultured on the matrixescontaining NOCC showed increased proliferation and secretion of three kinds of cytokines compared with thecontrol. Results of the in vivo wound healing study showed that matrixes incorporating NOCC showed markedlyenhanced wound healing compared with the control. Therefore, the above results clearly suggest that NOCC/COL matrixes containing CS or ADM can be potential wound dressings for clinical applications.